{"id":1540,"date":"2024-11-16T00:41:56","date_gmt":"2024-11-15T15:41:56","guid":{"rendered":"https:\/\/r-grasp.com\/?p=1540"},"modified":"2024-12-02T06:41:07","modified_gmt":"2024-12-01T21:41:07","slug":"%e3%80%80%e3%80%8e%e8%8b%a5%e5%b9%b4%e6%80%a7%e8%aa%8d%e7%9f%a5%e7%97%87%e3%81%ae%e6%8f%90%e5%94%b1%e3%81%8b%e3%82%89%e7%8f%be%e5%9c%a8%e3%81%be%e3%81%a7%e3%81%ae%e5%a4%89%e9%81%b7%e2%9e%81%e3%80%8f","status":"publish","type":"post","link":"https:\/\/r-grasp.com\/?p=1540","title":{"rendered":"\u3000\u300e\u82e5\u5e74\u6027\u8a8d\u77e5\u75c7\u306e\u63d0\u5531\u304b\u3089\u73fe\u5728\u307e\u3067\u306e\u5909\u9077\u2781\u300f\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n

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\u3053\u3061\u3089\u261d\u306e\u6570\u304c\u5897\u3048\u308b\u3060\u3051\u3001GRASPism\u3092\u767a\u4fe1\u3057\u305f\u3068\u3044\u3046\u30b7\u30f3\u30dc\u30eb\u306b\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u306e\u3067\u3001\u304a\u4ed8\u304d\u5408\u3044\u306e\u7a0b\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059(\u7b11)<\/p>\n\n\n\n

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3. 20\u4e16\u7d00\u5f8c\u534a\uff1a\u8a8d\u77e5\u75c7\u306e\u7d71\u5408\u7684\u7406\u89e3\u3068\u8a3a\u65ad\u57fa\u6e96\u306e\u6539\u5b9a<\/strong><\/p>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

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4. 21\u4e16\u7d00\uff1a\u547c\u79f0\u5909\u66f4\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u767a\u898b<\/strong><\/p>\n\n\n\n

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2000\u5e74\u4ee3\u4ee5\u964d\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u521d\u8001\u671f\u8a8d\u77e5\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u8907\u6570\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u7279\u306b\u65e9\u767a\u578b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3044\u3066\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\uff08APP\uff09\u203b1<\/sup>\u3084\u30d7\u30ec\u30bb\u30cb\u30ea\u30f3\uff08PSEN1\u3001PSEN2\uff09\u203b2<\/sup>\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a2\u30df\u30ed\u30a4\u30c9PET\u203b3<\/sup>\u3084\u8840\u6db2\u691c\u67fb\u306a\u3069\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u203b4<\/sup>\u6280\u8853\u3082\u9032\u5c55\u3057\u3001\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u524d\u6bb5\u968e\u304b\u3089\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

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\n\n\n\n

\u25c6\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

1. \u521d\u8001\u671f\u8a8d\u77e5\u75c7\u306e\u6982\u5ff5\u306e\u63d0\u5531\u306b\u95a2\u3059\u308b\u8ad6\u6587<\/strong><\/p>\n\n\n\n

    \n
  • Alzheimer, A. (1907).<\/strong> “\u00dcber eine eigenartige Erkrankung der Hirnrinde.” Allgemeine Zeitschrift f\u00fcr Psychiatrie und psychisch-gerichtliche Medizin<\/em>, 64: 146-148.<\/li>\n<\/ul>\n\n\n\n

    2. \u8a8d\u77e5\u75c7\u306e\u5206\u985e\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u78ba\u7acb\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong><\/p>\n\n\n\n

      \n
    • Blessed, G., Tomlinson, B. E., & Roth, M. (1968).<\/strong> “The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.” British Journal of Psychiatry<\/em>, 114(512), 797-811.<\/li>\n<\/ul>\n\n\n\n

      3. DSM\u3084ICD\u306b\u3088\u308b\u8a3a\u65ad\u57fa\u6e96\u306e\u6539\u5b9a\u3068\u7d71\u5408\u7684\u7406\u89e3\u306e\u9032\u5c55<\/strong><\/p>\n\n\n\n

        \n
      • American Psychiatric Association. (1987).<\/strong> Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.) (DSM-III-R)<\/em>.<\/li>\n\n\n\n
      • World Health Organization. (1992).<\/strong> The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines.<\/em><\/li>\n<\/ul>\n\n\n\n

        4. \u907a\u4f1d\u5b50\u7814\u7a76\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong><\/p>\n\n\n\n

          \n
        • Goate, A., Chartier-Harlin, M. C., Mullan, M., et al. (1991).<\/strong> “Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease.” Nature<\/em>, 349(6311), 704-706.<\/li>\n\n\n\n
        • Rabinovici, G. D., & Jagust, W. J. (2009).<\/strong> “Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.” Behavioral Neurology<\/em>, 21(1), 117-128.<\/li>\n<\/ul>\n\n\n\n

          5. \u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306e\u9032\u5c55\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong><\/p>\n\n\n\n

            \n
          • Livingston, G., Sommerlad, A., Orgeta, V., et al. (2017).<\/strong> “Dementia prevention, intervention, and care.” The Lancet<\/em>, 390(10113), 2673-2734.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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